Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition.

ABSTRACT:

Background & aims

Elements of field cancerization, including atrophic gastritis, metaplasia, and dysplasia, promote gastric cancer development in association with chronic inflammation. However, it remains unclear how stroma changes during carcinogenesis and how the stroma contributes to progression of gastric preneoplasia. Here we investigated heterogeneity of fibroblasts, one of the most important elements in the stroma, and their roles in neoplastic transformation of metaplasia.

Methods

We used single-cell transcriptomics to evaluate the cellular heterogeneity of mucosal cells from patients with gastric cancer. Tissue sections from the same cohort and tissue microarrays were used to identify the geographical distribution of distinct fibroblast subsets. We further evaluated

SUBMITTER: Lee SH 

PROVIDER: S-EPMC10375042 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature