Multicellular Bioprinting of Biomimetic Inks for Tendon-to-Bone Regeneration.

ABSTRACT: Tendon-to-bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in the failure of the interface repair. Biomimetic strategies have attracted enormous attention in the field of complex structure regeneration because they can meet the different physiological requirements of multiple tissues. Herein, a biomimetic ink mimicking tendon/bone tissues is developed by combining tendon/bone-related cells and Mo-containing silicate (MS) bioceramics. Subsequently, biomimetic multicellular scaffolds are fabricated to achieve the simulation of the hierarchical structure and cellular composition of tendon-to-bone interfac

SUBMITTER: Du L 

PROVIDER: S-EPMC10375072 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature