Laccase-Based Self-Amplifying Catalytic System Enables Efficient Antibiotic Degradation for Sustainable Environmental Remediation.

ABSTRACT: Antibiotic contamination poses potential risks to ecosystems and human health. Laccase (LAC) has emerged as a promising biocatalyst for the oxidation of environmentally toxic contaminants with high catalytic efficiency; however, its large-scale application is hindered by enzyme costs and dependency on redox mediators. Herein, a novel self-amplifying catalytic system (SACS) for antibiotic remediation that does not require external mediators is developed. In SACS, a natural mediator-regenerating koji with high-activity LAC, derived from lignocellulosic waste, initiates the chlortetracycline (CTC) degradation. Subsequently, an intermediate product, CTC327, identified as an active mediator for LAC via molecular docking, is formed and then starts a renewable reaction cycle, including CTC327-LAC

SUBMITTER: Xia Y 

PROVIDER: S-EPMC10375088 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature