DCM Support: cell therapy and circulatory support for dilated cardiomyopathy patients with severe ventricular impairment.

ABSTRACT:

Aims

The DCM Support trial (NCT03572660) uses a percutaneous circulatory support device (Impella CP, Abiomed, Danvers, MA, USA) to improve the safety of an intracoronary cell infusion procedure in patients with dilated cardiomyopathy (DCM) and a severely reduced left ventricular ejection fraction (LVEF).

Methods and results

DCM Support is a single-site, single-arm Phase II trial enrolling 20 symptomatic DCM patients with an LVEF ≤ 35% despite optimal medical and device therapy. After 5 days of granulocyte colony-stimulating factor therapy and a subsequent bone marrow aspiration, patients undergo an intracoronary infusion of autologous bone-marrow-derived mononuclear cells. The Impella CP device is used to provide haemodynamic support during the infusion procedure. The trial'

SUBMITTER: Reid A 

PROVIDER: S-EPMC10375109 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature