Prognostic role of tissue plasminogen activator in coronary artery disease with or without aortic valve sclerosis.

ABSTRACT:

Aims

We sought to investigate the relationship between circulating tissue plasminogen activator (t-PA) level and long-term outcomes in stable coronary artery disease patients with or without aortic valve sclerosis (AVSc).

Methods and results

Serum levels of t-PA were determined in 347 consecutive stable angina patients with (n = 183) or without (n = 164) AVSc. Outcomes were prospectively recorded as planned clinic evaluations every 6 months up to 7 years. The primary endpoint was a composite of cardiovascular death and rehospitalization due to heart failure. The secondary endpoint included all-cause mortality, cardiovascular death, and rehospitalization due to heart failure. Serum t-PA was significantly higher in AVSc than in non-AVSc patients (2131.22 pg/mL vs. 1495.85 pg/m

SUBMITTER: Lin B 

PROVIDER: S-EPMC10375160 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature