Renal tubular damage and clinical outcome in heart failure with preserved ejection fraction and chronic kidney disease.

ABSTRACT:

Aims

Despite advances in heart failure (HF) treatment, HF with preserved ejection fraction (HFpEF) remains a health problem with a high mortality rate. HFpEF is composed of diverse phenogroups, of which patients with concomitant renal impairment have worse outcomes. Renal tubular damage (RTD) is associated with the development of HF and chronic kidney disease (CKD). However, the impact of RTD on HF progression in patients with HFpEF and CKD remains unclear. The aim of the present study was to examine whether RTD could predict HF-related events in patients with HFpEF and CKD.

Methods and results

We measured RTD markers, such as urinary β₂ -microglobulin to creatinine ratio (UBCR) and N-acetyl-β-d-glucosamidase (NAG) level, in 319 consecutive patients with HFpEF and

SUBMITTER: Otaki Y 

PROVIDER: S-EPMC10375165 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature