Sex differences in clinical characteristics and outcomes in patients undergoing heart transplantation.

ABSTRACT:

Aims

Whether sex affects selection for and outcomes after heart transplantation (HTx) remains unclear. We aimed to show sex differences in pre-transplant characteristics and outcomes after HTx.

Methods and results

From 1995 to 2019, 49 200 HTx recipients were prospectively enrolled in the Organ Procurement and Transplantation Network. Logistic regression models were used to evaluate clinical characteristics by sex. Multivariable Cox regression models were fitted to assess sex differences in all-cause mortality, cardiovascular mortality, graft failure, cardiac allograft vasculopathy (CAV), and malignancy. In 49 200 patients (median age 55 years, interquartile range 46-62; 24.6% women), 49 732 events occurred during a median follow-up of 8.1 years. Men were older than women, h

SUBMITTER: Kondziella C 

PROVIDER: S-EPMC10375178 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature