Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement.

ABSTRACT:

Aims

There is evidence to suggest that the subtype of aortic stenosis (AS), the degree of myocardial fibrosis (MF), and level of aortic valve calcification (AVC) are associated with adverse cardiac outcome in AS. Because little is known about their respective contribution, we sought to investigate their relative importance and interplay as well as their association with adverse cardiac events following transcatheter aortic valve replacement (TAVR).

Methods and results

One hundred consecutive patients with severe AS and indication for TAVR were prospectively enrolled between January 2017 and October 2018. Patients underwent transthoracic echocardiography, multidetector computed tomography, and left ventricular endomyocardial biopsies at the time of TAVR. The final study cohor

SUBMITTER: Evertz R 

PROVIDER: S-EPMC10375183 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature