Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity.

ABSTRACT: The existence of thousands of per- and polyfluoroalkyl substances (PFAS) and evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity and to move beyond one-chemical-at-a-time approaches to hazard assessment for this chemical class. The zebrafish model enables rapid assessment of large libraries of PFAS, powerful comparison of compounds in a single in vivo system, and evaluation across life stages and generations, and has led to significant advances in PFAS research in recent years. The focus of this review is to assess contemporary findings regarding PFAS toxicokinetics, toxicity and apical adverse health outcomes, and potential modes of action using the zebrafish model. Much of the peer-reviewed literature has focused on a small subset o

SUBMITTER: Rericha Y 

PROVIDER: S-EPMC10375317 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature