Protective effects of red orange (Citrus sinensis [L.] Osbeck [Rutaceae]) extract against UVA-B radiation-induced photoaging in Skh:HR-2 mice.

ABSTRACT:

Background/objectives

The skin is the outermost organ of the human body and plays a protective role against external environmental damages, such as sunlight and pollution, which affect anti-oxidant defenses and skin inflammation, resulting in erythema or skin reddening, immunosuppression, and epidermal DNA damage.

Materials/methods

The present study aimed to investigate the potential protective effects of red orange complex H extract (ROC) against ultraviolet (UV)-induced skin photoaging in Skh:HR-2 mice. ROC was orally administered at doses of 20, 40, and 80 mg/kg/day for 13 weeks, along with UV irradiation of the mice for 10 weeks.

Results

ROC improved UV-induced skin barrier parameters, including erythema, melanin production, transepidermal water loss, elasticity,

SUBMITTER: Kim YH 

PROVIDER: S-EPMC10375325 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature