Metabolic Recycling Enhances Proliferation in MYC-Transformed Lymphoma B Cells.

ABSTRACT: Relapses negatively impact cancer patient survival due to the tumorigenesis ability of surviving cancer cells post-therapy. Efforts are needed to better understand and combat this problem. This study hypothesized that dead cell debris post-radiation therapy creates an advantageous microenvironment rich in metabolic materials promoting the growth of remaining live cancer cells. In this study, live cancer cells are co-cultured with dead cancer cells eradicated by UV radiation to mimic a post-therapy environment. Isotopic labeling metabolomics is used to investigate the metabolic behavior of cancer cells grown in a post-radiation-therapy environment. It is found that post-UV-eradicated dead cancer cells serve as nutritional sources of "off-the-shelf" and precursor metabolites for surviving ca

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10375452 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature