A New Phase of Networking: The Molecular Composition and Regulatory Dynamics of Mammalian Stress Granules.

ABSTRACT: Stress granules (SGs) are cytosolic biomolecular condensates that form in response to cellular stress. Weak, multivalent interactions between their protein and RNA constituents drive their rapid, dynamic assembly through phase separation coupled to percolation. Though a consensus model of SG function has yet to be determined, their perceived implication in cytoprotective processes (e.g., antiviral responses and inhibition of apoptosis) and possible role in the pathogenesis of various neurodegenerative diseases (e.g., amyotrophic lateral sclerosis and frontotemporal dementia) have drawn great interest. Consequently, new studies using numerous cell biological, genetic, and proteomic methods have been performed to unravel the mechanisms underly

SUBMITTER: Millar SR 

PROVIDER: S-EPMC10375481 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature