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The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.

ABSTRACT: Chemical and molecular-based computers may be promising alternatives to modern silicon-based computers. In particular, hybrid systems, where tasks are split between a chemical medium and traditional silicon components, may provide access and demonstration of chemical advantages such as scalability, low power dissipation, and genuine randomness. This work describes the development of a hybrid classical-molecular computer (HCMC) featuring an electrochemical reaction on top of an array of discrete electrodes with a fluorescent readout. The chemical medium, optical readout, and electrode interface combined with a classical computer generate a feedback loop to solve several canonical optimization problems in computer science such as number partitioning and prime factorization. Importantly, the HCMC makes constructive use of experimental noise in the optical readout, a milestone for molecular systems, to solve these optimization problems, as opposed to in silico random number generation. Specifically, we show calculations stranded in local minima can consistently converge on a global minimum in the presence of experimental noise. Scalability of the hybrid computer is demonstrated by expanding the number of variables from 4 to 7, increasing the number of possible solutions by 1 order of magnitude. This work provides a stepping stone to fully molecular approaches to solving complex computational problems using chemistry.

SUBMITTER: Krasecki VK

PROVIDER: S-EPMC10375572 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.

Krasecki Veronica K VK Sharma Abhishek A Cavell Andrew C AC Forman Christopher C Guo Si Yue SY Jensen Evan Thomas ET Smith Mackinsey A MA Czerwinski Rachel R Friederich Pascal P Hickman Riley J RJ Gianneschi Nathan N Aspuru-Guzik Alán A Cronin Leroy L Goldsmith Randall H RH

ACS central science 20230714 7

Chemical and molecular-based computers may be promising alternatives to modern silicon-based computers. In particular, hybrid systems, where tasks are split between a chemical medium and traditional silicon components, may provide access and demonstration of chemical advantages such as scalability, low power dissipation, and genuine randomness. This work describes the development of a hybrid classical-molecular computer (HCMC) featuring an electrochemical reaction on top of an array of discrete ...[more]

PMID: 37521801

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Project description:This research paper develops a novel hybrid approach, called hybrid particle swarm optimization-teaching-learning-based optimization (hPSO-TLBO), by combining two metaheuristic algorithms to solve optimization problems. The main idea in hPSO-TLBO design is to integrate the exploitation ability of PSO with the exploration ability of TLBO. The meaning of "exploitation capabilities of PSO" is the ability of PSO to manage local search with the aim of obtaining possible better solutions near the obtained solutions and promising areas of the problem-solving space. Also, "exploration abilities of TLBO" means the ability of TLBO to manage the global search with the aim of preventing the algorithm from getting stuck in inappropriate local optima. hPSO-TLBO design methodology is such that in the first step, the teacher phase in TLBO is combined with the speed equation in PSO. Then, in the second step, the learning phase of TLBO is improved based on each student learning from a selected better student that has a better value for the objective function against the corresponding student. The algorithm is presented in detail, accompanied by a comprehensive mathematical model. A group of benchmarks is used to evaluate the effectiveness of hPSO-TLBO, covering various types such as unimodal, high-dimensional multimodal, and fixed-dimensional multimodal. In addition, CEC 2017 benchmark problems are also utilized for evaluation purposes. The optimization results clearly demonstrate that hPSO-TLBO performs remarkably well in addressing the benchmark functions. It exhibits a remarkable ability to explore and exploit the search space while maintaining a balanced approach throughout the optimization process. Furthermore, a comparative analysis is conducted to evaluate the performance of hPSO-TLBO against twelve widely recognized metaheuristic algorithms. The evaluation of the experimental findings illustrates that hPSO-TLBO consistently outperforms the competing algorithms across various benchmark functions, showcasing its superior performance. The successful deployment of hPSO-TLBO in addressing four engineering challenges highlights its effectiveness in tackling real-world applications.

Dataset Information

The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.

Publications

The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.

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