Changes in expression levels of erythrocyte and immune-related genes are associated with high altitude polycythemia.

ABSTRACT:

Background

As a chronic mountain sickness(CMS) with the highest incidence and the greatest harm, the pathogenesis of high altitude polycythemia (HAPC) is still not fully understood.

Methods

37 HAPC patients and 42 healthy subjects were selected from plateau, and peripheral venous blood samples were collected for transcriptome sequencing on Illumina NovaSeq platform. The sequenced data were analyzed by bioinformatics and phenotypic association analysis.

Results

The results showed significant differences in multiple clinical indicators including RBC and HGB et al. existed between HAPC and control. Based on the RNA-seq data, 550 genes with significant differential expression were identified in HAPC patients. GO and KEGG pathway enrichment analysis showed that the up-regu

SUBMITTER: Feng S 

PROVIDER: S-EPMC10375625 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature