Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.

ABSTRACT:

Background

Postoperative cognitive dysfunction (POCD) is a common neurological complication following anesthesia and surgery. Increasing evidence has demonstrated that neuroinflammation caused by systemic inflammatory responses during the perioperative period is a key factor in the occurrence of POCD. In addition, SMAD family member 7 (Smad7) has been confirmed to play vital roles in the pathogenesis and treatment of inflammatory diseases, such as inflammatory bowel disease. However, whether Smad7 participates in the regulatory process of neuroinflammation and apoptosis in the development of POCD is still unknown.

Methods

In this study, a POCD mouse model was constructed by unilateral nephrectomy under anesthesia, and cognitive function was assessed using the fear conditioni

SUBMITTER: Liu C 

PROVIDER: S-EPMC10375636 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature