Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease.

ABSTRACT:

Background

Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed for disease prevention. Altered methylation of ATP-binding cassette subfamily G member 1 (ABCG1) has been implicated in CHD but was mostly studied in Caucasians. Exploring the potential relationship between ABCG1 methylation in blood and CHD among the Chinese population would yield valuable insights.

Methods

Peripheral blood samples were obtained from a case-control study (287 CHD patients vs. 277 controls) and a prospective nested case-control study (171 CHD patients and 197 matched controls). DNA extraction and bisulfite-specific PCR amplification techniques were employed for sample processing. Quantitative assessment of methylation levels w

SUBMITTER: Jin J 

PROVIDER: S-EPMC10375639 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature