Radiomics using computed tomography to predict CD73 expression and prognosis of colorectal cancer liver metastases.

ABSTRACT:

Background

Finding a noninvasive radiomic surrogate of tumor immune features could help identify patients more likely to respond to novel immune checkpoint inhibitors. Particularly, CD73 is an ectonucleotidase that catalyzes the breakdown of extracellular AMP into immunosuppressive adenosine, which can be blocked by therapeutic antibodies. High CD73 expression in colorectal cancer liver metastasis (CRLM) resected with curative intent is associated with early recurrence and shorter patient survival. The aim of this study was hence to evaluate whether machine learning analysis of preoperative liver CT-scan could estimate high vs low CD73 expression in CRLM and whether such radiomic score would have a prognostic significance.

Methods

We trained an Attentive Interpretable Tabula

SUBMITTER: Saber R 

PROVIDER: S-EPMC10375693 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature