Preoperative serum bilirubin is an independent prognostic factor for curatively resected esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

This study examines prognostic value of preoperative serum bilirubin, including unconjugated bilirubin (UCB), conjugated bilirubin (CB), and total bilirubin (TB), in esophageal squamous cell carcinoma (ESCC) patients who underwent curative resection.

Methods

Between May 2010 and December 2012, a total of 351 ESCC patients were retrospectively reviewed. All the patients underwent curative resection as their primary treatment. Clinicopathological features and overall survival (OS) rate were investigated. Kaplan-Meier curves were used to calculate the OS rate, and the prognostic factors were identified by Cox regression model. Besides, the potential inhibition effect of UCB on ESCC was investigated with both in vitro and in vivo models.

Results

The higher-level g

SUBMITTER: Huang X 

PROVIDER: S-EPMC10375695 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature