Landscape of internal N7-methylguanosine of long non-coding RNA modifications in resistant acute myeloid leukemia.

ABSTRACT:

Background

Growing evidence indicates that RNA methylation plays a fundamental role in epigenetic regulation, which is associated with the tumorigenesis and drug resistance. Among them, acute myeloid leukemia (AML), as the top acute leukemia for adults, is a deadly disease threatening human health. Although N7-methylguanosine (m7G) has been identified as an important regulatory modification, its distribution has still remained elusive.

Methods

The present study aimed to explore the long non-coding RNA (lncRNA) functional profile of m7G in AML and drug-resistant AML cells. The transcriptome-wide m7G methylation of lncRNA was analyzed in AML and drug-resistant AML cells. RNA MeRIP-seq was performed to identify m7G peaks on lncRNA and differences in m7G distribution between AML

SUBMITTER: Han J 

PROVIDER: S-EPMC10375699 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature