The cervical transcriptome changes during the menstrual cycle but does not predict the window of implantation.

ABSTRACT:

Introduction

The expression of genes in female reproductive organs is influenced by the cyclic changes in hormone levels during the menstrual cycle. While the molecular changes in the endometrium that facilitate embryo implantation have been extensively studied, there is limited knowledge about the impact of the menstrual cycle on cervical cells. Cervical cells can be easily and routinely collected using a cytobrush during gynecological examination, offering a standardized approach for diagnostic testing. In this study we investigated how the transcriptome of cervical cells changes during the menstrual cycle and assessed the utility of these cells to determine endometrial receptivity.

Methods

Endocervical cells were collected with cytobrushes from 16 healthy women at differe

SUBMITTER: Pathare ADS 

PROVIDER: S-EPMC10375708 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature