Evaluation of the immunoprotective effects of eight recombinant proteins from Baylisascaris schroederi in mice model.

ABSTRACT:

Background

Baylisascaris schroederi is the most common and harmful intestinal parasitic nematode of giant pandas, causing ascariasis. Although drug deworming is the main measure to control ascariasis in captive giant pandas, prolonged and repeated use of deworming drugs might induce resistance in nematodes and drug residues in giant pandas. Therefore, developing a safe and effective vaccine might provide a novel strategy to prevent ascariasis in captive giant pandas.

Methods

Four highly expressed secretome genes encoding excretory and secretory proteins of B. schroederi, including transthyretin-like protein 46 (BsTLP), uncharacterized protein (BsUP), hypothetical protein 1 (BsHP1), and hypothetical protein 2 (BsHP2) and four functional genes [(encoding Galectin (BsGAL), glut

SUBMITTER: Xiong L 

PROVIDER: S-EPMC10375773 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature