A bioinformatic investigation of proteasome and autophagy expression in the central nervous system.

ABSTRACT: The ubiquitin proteasome system (UPS) and autophagy lysosome pathway (ALP) are crucial in the control of protein quality. However, data regarding the relative significance of UPS and ALP in the central nervous system (CNS) are limited. In the present study, using publicly available data, we computed the quantitative expression status of UPS- and ALP-related genes and their products in the CNS as compared with that in other tissues and cells. We obtained human and mouse gene expression datasets from the reference expression dataset (RefEx) and Genevestigator (a tool for handling curated transcriptomic data from public repositories) as well as human proteomics data from the proteomics database (ProteomicsDB). The expression levels of genes and proteins in four categories-ubiquitin, proteasom

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC10375789 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature