Piceatannol as an Antiviral Inhibitor of PRV Infection In Vitro and In Vivo.

ABSTRACT: Pseudorabies virus (PRV) belongs to the family Herpesviridae. PRV has a wide host range and can cause cytopathic effects (CPEs) in PK-15 cells. Therefore, PRV was used as a model to study the antiviral activity of piceatannol. The results showed that piceatannol could restrain PRV multiplication in PK-15 cells in a dose-dependent manner. The 50% inhibitory concentration (IC₅₀) was 0.0307 mg/mL, and the selectivity index (SI, CC₅₀/IC₅₀) was 3.68. Piceatannol could exert an anti-PRV effect by reducing the transcription level of viral genes, inhibiting PRV-induced apoptosis and elevating the levels of IL-4, TNF-α and IFN-γ in the serum of mice. Animal experiments showed that piceatannol could delay the onset of disease, reduce the viral load in the brain and k

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10375968 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature