Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.

ABSTRACT: Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes and microglia, among the brain's non-neuronal "glia" cell populations, play a pivotal role in neurodevelopment and predisposition to and initiation of disease throughout lifespan. One of the most common neurodevelopmental disorders manifesting between 1-4 years of age is the autism spectrum disorder (ASD). A pathological glial-neuronal interplay is thought to increase the risk for clinical manifestation of ASD in at-risk children, but the mechanisms remain poorly understood, and integrative, multi-scale models are needed. We propose a model that integrates the data across the scales of physiological organization, from genome to phenotype, and provides a foundation to explain th

SUBMITTER: Frasch MG 

PROVIDER: S-EPMC10375982 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature