Biological Oxidations and Nitrations Promoted by the Hemin-Aβ₁₆ Complex.

ABSTRACT: Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer's disease. Hemin contributes to the development of the disease as it possesses redox properties and its level increases in pathological conditions or traumatic brain injuries. The aim of this work was to deepen the investigation of the reactivity of the hemin-Aβ₁₆ complex, considering its ability to catalyze oxidation and nitration reactions. We performed kinetic studies in the presence of hydrogen peroxide and nitrite with phenolic and catechol substrates, as well as mass spectrometry studies to investigate the modifications occurring on the peptide itself. The kinetic constants were similar for oxidation and nitration reactions, and their values suggest that the hemin-Aβ₁₆ compl

SUBMITTER: De Caro S 

PROVIDER: S-EPMC10376006 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature