Ontology highlight
ABSTRACT:
SUBMITTER: Mohle L
PROVIDER: S-EPMC10376064 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Möhle Luisa L Stefan Katja K Bascuñana Pablo P Brackhan Mirjam M Brüning Thomas T Eiriz Ivan I El Menuawy Ahmed A van Genderen Sylvie S Santos-García Irene I Górska Anna Maria AM Villa María M Wu Jingyun J Stefan Sven Marcel SM Pahnke Jens J
Biology 20230629 7
Alzheimer's disease (AD), the leading cause of dementia, is a growing health issue with very limited treatment options. To meet the need for novel therapeutics, existing drugs with additional preferred pharmacological profiles could be recruited. This strategy is known as 'drug repurposing'. Here, we describe dimethyl fumarate (DMF), a drug approved to treat multiple sclerosis (MS), to be tested as a candidate for other brain diseases. We used an APP-transgenic model (APPtg) of senile β-amyloido ...[more]