Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption.

ABSTRACT: Recent studies have confirmed that lung microvascular endothelial injury plays a critical role in the pathophysiology of COVID-19. Our group and others have demonstrated the beneficial effects of H₂S in several pathological processes and provided a rationale for considering the therapeutic implications of H₂S in COVID-19 therapy. Here, we evaluated the effect of the slow-releasing H₂S donor, GYY4137, on the barrier function of a lung endothelial cell monolayer in vitro, after challenging the cells with plasma samples from COVID-19 patients or inactivated SARS-CoV-2 virus. We also assessed how the cytokine/chemokine profile of patients' plasma, endothelial barrier permeability, and disease severity correlated with each other. Alterations in barrier permeabil

SUBMITTER: Escaffre O 

PROVIDER: S-EPMC10376201 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature