Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity.

ABSTRACT: Oxidative stress surrounding cancer cells provides them with certain growth and survival advantages necessary for disease progression. In this context, Se-containing molecules have gained attention due to their anticancer and antioxidant activity. In our previous work, we synthesized a library of 39 selenoesters containing functional groups commonly present in natural products (NP), which showed potent anticancer activity, but did not demonstrate high radical scavenger activity. Thus, 20 novel Se derivatives resembling NP have been synthesized presenting acylselenourea functionality in their structures. Radical scavenger activity was tested using DPPH assay and in vitro protective effects against ROS-induced cell death caused by H₂O₂. Additionally, antiproliferative a

SUBMITTER: Astrain-Redin N 

PROVIDER: S-EPMC10376326 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature