Impaired NRF2 Inhibits Recovery from Ischemic Reperfusion Injury in the Aging Kidney.

ABSTRACT: Deteriorating kidney function is frequently observed in the elderly population, as well as vulnerability to acute kidney failure, such as ischemic/reperfusion injury (IRI), and inadequate recovery from IRI is one of the mechanisms of kidney dysfunction in the elderly. The potential mediators in the progression of kidney dysfunction in the aging kidney have not yet been clearly revealed. In this study, we investigated the role of nuclear factor erythroid 2-related factor 2 (NRF2), which is an essential regulator of cellular redox homeostasis, in restoring kidney function after IRI in the aging kidney. NRF2 expression decreased significantly in the kidneys of old mice, as well as histologic and functional renal recovery after IRI; 45-min renal pedicle clamping was retarded in old compared wi

SUBMITTER: Jo MJ 

PROVIDER: S-EPMC10376352 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature