VDR Gene Single Nucleotide Polymorphisms and Autoimmunity: A Narrative Review.

ABSTRACT: The vitamin D/Vitamin D receptor (VDR) axis is crucial for human health as it regulates the expression of genes involved in different functions, including calcium homeostasis, energy metabolism, cell growth and differentiation, and immune responses. In particular, the vitamin D/VDR complex regulates genes of both innate and adaptive immunity. Autoimmune diseases are believed to arise from a genetic predisposition and the presence of triggers such as hormones and environmental factors. Among these, a role for Vitamin D and molecules correlated to its functions has been repeatedly suggested. Four single nucleotide polymorphisms (SNPs) of the VDR gene, ApaI, BsmI, TaqI, and FokI, in particular, have been associated with autoimmune disorders. The presence of

SUBMITTER: Agliardi C 

PROVIDER: S-EPMC10376382 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature