Exploring the Regulatory Role of XIST-microRNAs/mRNA Network in Circulating CD4⁺ T Cells of Hepatocellular Carcinoma Patients.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common cancers and the main cause of cancer-related death globally. Immune dysregulation of CD4⁺ T cells has been identified to play a role in the development of HCC. Nevertheless, the underlying molecular pathways of CD4⁺ T cells in HCC are not completely known. Thus, a better understanding of the dysregulation of the lncRNA-miRNA/mRNA network may yield novel insights into the etiology or progression of HCC. In this study, circulating CD4⁺ T cells were isolated from the whole blood of 10 healthy controls and 10 HCC patients for the next-generation sequencing of the expression of lncRNAs, miRNAs, and mRNAs. Our data showed that there were different expressions of 34 transcripts (2 lncRNAs, XISTs, and MIR222H

SUBMITTER: Huang LH 

PROVIDER: S-EPMC10376435 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature