Glucocorticoid withdrawal syndrome following surgical remission of endogenous hypercortisolism: a longitudinal observational study.

ABSTRACT:

Objective

Glucocorticoid withdrawal syndrome (GWS) is a scarcely studied phenomenon that complicates the recovery following surgical remission of hypercortisolism. We aimed to characterize the presence and trajectory of glucocorticoid withdrawal symptoms in the postoperative period and to determine presurgical predictors of GWS severity.

Design

Longitudinal observational study.

Methods

Glucocorticoid withdrawal symptoms were prospectively evaluated weekly for the first 12 weeks following surgical remission of hypercortisolism. Quality of life (CushingQoL and Short-Form-36) and muscle function (hand grip strength and sit-to-stand test) were assessed at the baseline and at 12 weeks after surgery.

Results

Prevalent symptoms were myalgias and arthralgias (50%), fat

SUBMITTER: Zhang CD 

PROVIDER: S-EPMC10376560 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature