Cognitive Alterations in Addictive Disorders: A Translational Approach.

ABSTRACT: The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in

SUBMITTER: Gasparyan A 

PROVIDER: S-EPMC10376598 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature