Histopathological differences between vitiligo and lichen sclerosus et atrophicus using quantitative immunohistochemical analysis.

ABSTRACT:

Introduction

Lichen sclerosus et atrophicus (LS) is rare skin condition characterized by the presence of whitish patches primarily affecting the genital and perianal areas, though it can occur other parts of the body. LS may result in skin depigmentation without textural changes and should be differentiated from vitiligo. However, the histopathological features of hypopigmentation during vitiligo and LS have rarely been compared and have not been precisely described using quantitative immunohistochemical analysis. This study, therefore, aimed to investigate and compare the pigmentary characteristics of LS and vitiligo lesions using histochemical and immunohistochemical staining.

Methods

We included 31 and 46 patients diagnosed with LS and vitiligo, respectively, at Ajou Univ

SUBMITTER: Park YJ 

PROVIDER: S-EPMC10376688 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature