Voriconazole Pharmacokinetics in Critically Ill Patients and Extracorporeal Membrane Oxygenation Support: A Retrospective Comparative Case-Control Study.

ABSTRACT: Voriconazole, an antifungal agent, displays high intra- and inter-individual variability. The predictive pharmacokinetic (PK) index requires a minimum plasma concentration (C_min) in patient serum of between 1-5.5 mg/L. It is common to encounter fungal infections in patients undergoing extracorporeal membrane oxygenation (ECMO) support, and data regarding voriconazole PK changes during ECMO are scarce. Our study compared voriconazole PKs in patients with and without ECMO support in a retrospective cohort of critically-ill patients. Fifteen patients with 26 voriconazole C_min determinations in the non-ECMO group and nine patients with 27 voriconazole C_min determinations in the ECMO group were recruited. The ECMO group had lower C_min (0.38 ± 2.98 vs.

SUBMITTER: Ronda M 

PROVIDER: S-EPMC10376825 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature