Development of cortical surface area and gyrification in attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Delineation of the cortical anomalies underpinning attention-deficit/hyperactivity disorder (ADHD) can powerfully inform pathophysiological models. We previously found that ADHD is characterized by a delayed maturation of prefrontal cortical thickness. We now ask if this extends to the maturation of cortical surface area and gyrification.

Methods

Two hundred thirty-four children with ADHD and 231 typically developing children participated in the study, with 837 neuroanatomic magnetic resonance images acquired longitudinally. We defined the developmental trajectories of cortical surfaces and gyrification and the sequence of cortical maturation, as indexed by the age at which each cortical vertex attained its peak surface area.

Results

In both groups, the mat

SUBMITTER: Shaw P 

PROVIDER: S-EPMC10376909 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature