Neuromedin B-Expressing Neurons in the Retrotrapezoid Nucleus Regulate Respiratory Homeostasis and Promote Stable Breathing in Adult Mice.

ABSTRACT: Respiratory chemoreceptor activity encoding arterial Pco₂ and Po₂ is a critical determinant of ventilation. Currently, the relative importance of several putative chemoreceptor mechanisms for maintaining eupneic breathing and respiratory homeostasis is debated. Transcriptomic and anatomic evidence suggests that bombesin-related peptide Neuromedin-B (Nmb) expression identifies chemoreceptor neurons in the retrotrapezoid nucleus (RTN) that mediate the hypercapnic ventilatory response, but functional support is missing. In this study, we generated a transgenic Nmb-Cre mouse and used Cre-dependent cell ablation and optogenetics to test the hypothesis that RTN ^Nmb neurons are necessary for the CO₂-dependent drive to breathe in adu

SUBMITTER: Souza GMPR 

PROVIDER: S-EPMC10376939 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature