Prediction of CD44 Structure by Deep Learning-Based Protein Modeling.

ABSTRACT: CD44 is a cell surface glycoprotein transmembrane receptor that is involved in cell-cell and cell-matrix interactions. It crucially associates with several molecules composing the extracellular matrix, the main one of which is hyaluronic acid. It is ubiquitously expressed in various types of cells and is involved in the regulation of important signaling pathways, thus playing a key role in several physiological and pathological processes. Structural information about CD44 is, therefore, fundamental for understanding the mechanism of action of this receptor and developing effective treatments against its aberrant expression and dysregulation frequently associated with pathological conditions. To date, only the structure of the hyaluronan-binding domain (HABD) of CD44 has been experimentally

SUBMITTER: Camponeschi C 

PROVIDER: S-EPMC10376988 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature