Selection of tRNA Genes in Human Breast Tumours Varies Substantially between Individuals.

ABSTRACT: Abnormally elevated expression of tRNA is a common feature of breast tumours. Rather than a uniform increase in all tRNAs, some are deregulated more strongly than others. Elevation of particular tRNAs has been associated with poor prognosis for patients, and experimental models have demonstrated the ability of some tRNAs to promote proliferation or metastasis. Each tRNA isoacceptor is encoded redundantly by multiple genes, which are commonly dispersed across several chromosomes. An unanswered question is whether the consistently high expression of a tRNA in a cancer type reflects the consistent activation of the same members of a gene family, or whether different family members are activated from one patient to the next. To address this question, we interrogated ChIP-seq data to determine

SUBMITTER: Butterfield SP 

PROVIDER: S-EPMC10377016 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature