Microbiome Alterations and Alzheimer's Disease: Modeling Strategies with Transgenic Mice.

ABSTRACT: In the last decade, the role of the microbiota-gut-brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer's disease (AD) and diabetes, respectively. Notably, a balanced gut microbiota contributes to the epithelial intestinal barrier maintenance, modulates the host immune system, and releases neurotransmitters and/or neuroprotective short-chain fatty acids. However, dysbiosis may provoke immune dysregulation, impacting neuroinflammation through peripheral-central immune communication. Moreover, lipopolysaccharide or detrimental microbial end-products can cross the blood-brain barrier and induce or at least potentiate the neuropathological progression of AD. Thus, after repeated failure to find a cure for this dementia, a ne

SUBMITTER: Lopez-Villodres JA 

PROVIDER: S-EPMC10377071 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature