Shapes and Patterns of Heme-Binding Motifs in Mammalian Heme-Binding Proteins.

ABSTRACT: Heme is a double-edged sword. On the one hand, it has a pivotal role as a prosthetic group of hemoproteins in many biological processes ranging from oxygen transport and storage to miRNA processing. On the other hand, heme can transiently associate with proteins, thereby regulating biochemical pathways. During hemolysis, excess heme, which is released into the plasma, can bind to proteins and regulate their activity and function. The role of heme in these processes is under-investigated, with one problem being the lack of knowledge concerning recognition mechanisms for the initial association of heme with the target protein and the formation of the resulting complex. A specific heme-binding sequence motif is a prerequisite for such complex formation. Although numerous short signature seque

SUBMITTER: Rathod DC 

PROVIDER: S-EPMC10377097 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature