Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia.

ABSTRACT: Frontline acute myeloid leukemia (AML) treatment is determined by a combination of patient and genetic factors. This includes patient fitness (i.e., comorbidities that increase the risk of treatment-related mortality) and genetic characteristics, including cytogenetic events and gene mutations. In older unfit patients, the standard of care treatment is typically venetoclax (VEN) combined with hypomethylating agents (HMA). Recently, several drugs have been developed targeting specific genomic subgroups of AML patients, enabling individualized therapy. This has resulted in investigations of doublet and triplet combinations incorporating VEN aimed at overcoming known resistance mechanisms and improving outcomes in older patients with AML. These combinations include isocitrate dehydrogenase-1/

SUBMITTER: Oyogoa E 

PROVIDER: S-EPMC10377106 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature