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Non-Invasive and Label-Free On-Chip Impedance Monitoring of Heatstroke.


ABSTRACT: Heatstroke (HS) is a life-threatening injury requiring neurocritical care which could lead to central nervous system dysfunction and severe multiple organ failure syndrome. The cell-cell adhesion and cell permeability are two key factors for characterizing HS. To investigate the process of HS, a biochip-based electrical model was proposed and applied to HS. During the process, the value of TEER is associated with cell permeability and CI which represents cell-cell adhesion decreases that are consistent with the reduction in cell-cell adhesion and cell permeability characterized by proteins (occludin, VE-Cadherin and ZO-1) and RNA level. The results imply that the model can be used to monitor the biological process and other biomedical applications.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10377158 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Non-Invasive and Label-Free On-Chip Impedance Monitoring of Heatstroke.

Zhao Yueli Y   Fan Weihua W   Liu Anwei A   Pan Shihua S   Xu Chongxiao C   Peng Hailun H   Yin Bingling B   Wang Xiaodong X   Dong Jianhua J   Pan Zhiguo Z  

Biosensors 20230627 7


Heatstroke (HS) is a life-threatening injury requiring neurocritical care which could lead to central nervous system dysfunction and severe multiple organ failure syndrome. The cell-cell adhesion and cell permeability are two key factors for characterizing HS. To investigate the process of HS, a biochip-based electrical model was proposed and applied to HS. During the process, the value of TEER is associated with cell permeability and C<sub>I</sub> which represents cell-cell adhesion decreases t  ...[more]

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