Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy.

ABSTRACT: Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. The limited effectiveness of conventional therapies has prompted the search for new approaches to target this disease. Recent evidence suggests that distinct programmed cell death mechanisms, namely, apoptosis, ferroptosis, pyroptosis and necroptosis, play a critical role in the development and progression of cholangiocarcinoma. This review aims to summarize the current knowledge on the role of programmed cell death in cholangiocarcinoma and its potential implications for the development of novel therapies. Several studies have shown that the dysregulation of apoptotic signaling pathways contributes to cholangiocarcinoma tumorigenesis and resistance to treatment. Similarly, ferroptosis, pyroptosis and necroptosis

SUBMITTER: Scimeca M 

PROVIDER: S-EPMC10377326 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature