Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells.

ABSTRACT: Most patients who die of cancer do so from its metastasis to other organs. The calcium-binding protein S100A4 can induce cell migration/invasion and metastasis in experimental animals and is overexpressed in most human metastatic cancers. Here, we report that a novel inhibitor of S100A4 can specifically block its increase in cell migration in rat (IC₅₀, 46 µM) and human (56 µM) triple negative breast cancer (TNBC) cells without affecting Western-blotted levels of S100A4. The moderately-weak S100A4-inhibitory compound, US-10113 has been chemically attached to thalidomide to stimulate the proteasomal machinery of a cell. This proteolysis targeting chimera (PROTAC) RGC specifically eliminates S100A4 in the rat (IC₅₀, 8 nM) and human TNBC (IC₅₀, 3.2 nM) cell li

SUBMITTER: Ismail TM 

PROVIDER: S-EPMC10377353 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature