A Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications.

ABSTRACT: Over the past few decades, drug-induced liver damage (DILI) has become a serious public health problem due to drug abuse. Among multifarious reactive oxygen species, mounting evidence attests that ClO^- has been used as a potential biomarker in DILI. In this work, a new "turn-on" fluorescent probe 1 was designed and synthesized by modifying 4'-hydroxybiphenyl-4-carbonitrile (dye 2) with N, N-dimethylthiocarbamate as a response site for detecting ClO^-. Probe 1 displayed a low detection limit (72 nM), fast response time (30 s), wide pH operating range (6-8), great tissue penetration, large Stokes shift (125 nm) and 291-fold fluorescence enhancement at 475 nm in the mapping of ClO^-. Probe 1 could trace amounts of exogenous and

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10377358 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature