Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.

ABSTRACT: The SARS-CoV-2 virus has infected more than 261 million people and has led to more than 5 million deaths in the past year and a half¹ ( https://www.who.org/ ). Individuals with SARS-CoV-2 infection typically develop mild-to-severe flu-like symptoms, whereas infection of a subset of individuals leads to severe-to-fatal clinical outcomes². Although vaccines have been rapidly developed to combat SARS-CoV-2, there has been a dearth of antiviral therapeutics. There is an urgent need for therapeutics, which has been amplified by the emerging threats of variants that may evade vaccines. Large-scale efforts are underway to identify antiviral drugs. Here we screened approximately 18,000 drugs for antiviral activity using live virus infection in human respiratory cells and vali

SUBMITTER: Schultz DC 

PROVIDER: S-EPMC10377386 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature