A Biomimetic Polymer for the Extraction and Purification of Superior Analogues of Amphotericin B.

ABSTRACT: Amphotericin B has been an essential drug in the fight against leishmaniasis and fungal pathogens for decades, and has more recently gained attention for the very limited microbial resistance displayed against it. However, its toxicity has restricted its use to only the most severe cases of disease, and attempts to reduce these ill effects via formulation have had only minor success. Genetic engineering has allowed the development of superior amphotericin analogues, notably 16-descarboxyl-16-methyl amphotericin B (MeAmB), which shows a ten-fold reduction in toxicity in addition to a slight improvement in therapeutic activity. However, MeAmB is difficult to extract from its bacterial source and purify. Presented here is an alternative method of MeAmB purification. A biomimetic polymer with

SUBMITTER: Cowen T 

PROVIDER: S-EPMC10377485 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature