Identifying Microbiome Dynamics in Pediatric IBD: More than a Family Matter.

ABSTRACT:

Background

Pediatric inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease that affects both children and adolescents. Symptoms can significantly affect a child's growth, development, and quality of life, making early diagnosis and effective management crucial. This study focuses on treatment-naïve pediatric IBD patients and their immediate families to identify the role of the microbiome in disease onset.

Methods

Nine families with pediatric IBD were recruited, comprising seven drug-naïve Crohn's disease (CD) patients and two drug-naïve ulcerative colitis (UC) patients, as well as twenty-four healthy siblings/parents. Fecal samples were collected for 16S ribosomal RNA gene sequencing and bioinformatics analysis.

Results

We identified patterns o

SUBMITTER: Dovrolis N 

PROVIDER: S-EPMC10377534 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature