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Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review.

ABSTRACT: Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in myeloid precursor cells. AML is one of the most common types of acute leukemia in adults; however, it is relatively rare overall, comprising about 1% of all cancers. In the last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds of thousands and millions of variants across many human genomes to discover genetic polymorphisms associated with a particular disease or phenotype. In oncology, GWAS has been performed in almost every commonly occurring cancer. Despite the increasing number of studies published regarding other malignancies, there is a paucity of GWAS studies for AML. In this review article, we will summarize the current status of GWAS in AML.

SUBMITTER: Marrero RJ

PROVIDER: S-EPMC10377605 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review.

Marrero Richard J RJ Lamba Jatinder K JK

Cancers 20230712 14

Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in myeloid precursor cells. AML is one of the most common types of acute leukemia in adults; however, it is relatively rare overall, comprising about 1% of all cancers. In the last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds of thousands and millions of variants across many human genomes to discover genetic polymorphi ...[more]

PMID: 37509244

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